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July 10, 2026The FASEB Journal0 citations

EXPRESSION OF CONCERN : HIV ‐1 Tat Regulates Cyclin B1 by Promoting Both Expression and Degradation

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Key Points

  • The article discusses the regulation of Cyclin B1 by HIV-1 Tat through both promoting expression and degradation.
  • Concerns regarding image duplication in immunoblot figures were identified and raised by third parties.
  • Prior articles investigated the interplay between HIV-1 Tat and Cyclin B1.
  • Expression of concern issued due to duplication found in Actin and Cyclin B1 immunoblots.
  • No clarification on concerns received from authors due to difficulty in verifying contact details.

Abstract

EXPRESSION OF CONCERN: S.-M. Zhang, Y. Sun, R. Fan, Q.-Z. Xu, X.-D. Liu, X. Zhang, Y. Wang, and P.-K. Zhou, “ HIV-1 Tat Regulates Cyclin B1 by Promoting Both Expression and Degradation,” The FASEB Journal 24, no. 2 (2010): 495–503, https://doi.org/10.1096/fj.09-143925. This Expression of Concern is for the above article, published online on 13 October 2009 in Wiley Online Library (wileyonlinelibrary.com) and has been published by agreement between the journal Editor-in-Chief, Loren E. Wold; the Federation of American Societies for Experimental Biology; and Wiley Periodicals LLC. The Expression of Concern has been agreed due to concerns raised by third parties. Specifically, image duplication between the Actin immunoblot in Figure 1A and the Actin immunoblot in Figure 1B, and between the Cyclin B1 immunoblot in Figure 1B and the Cyclin B1 immunoblot in Figure 1C have been detected. The authors were notified of the concerns using the available contact information; however, due to the time elapsed since publication, current contact details could not be verified. As no clarification regarding the concerns could be obtained, the journal has decided to issue an Expression of Concern to inform and alert readers.

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Cite This Study

A 2026 study studied this question.

synapsesocial.com/papers/6a508b536eeac72a437a016dhttps://doi.org/10.1096/fsb2.72107
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