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July 10, 2026JAMA Cardiology0 citations

Finerenone and Blood Pressure in Heart Failure With Mildly Reduced or Preserved Ejection Fraction

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JOJ OstrominskiBCBrian L. ClaggettIKIan J. Kulac

Key Result

Finerenone was analyzed to assess if it lowers blood pressure and if its cardiovascular benefits in HFmrEF or HFpEF depend on baseline blood pressure or blood pressure reduction.

Key Points

  • This trial aims to determine if finerenone lowers blood pressure and if its benefits depend on baseline blood pressure levels.
  • Randomized clinical trial design
  • Patients with mildly reduced or preserved ejection fraction heart failure
  • Analysis of blood pressure reduction and cardiovascular outcomes
  • Finerenone significantly reduced blood pressure compared to control, with an average reduction of X mmHg (exact figure needed).
  • Cardiovascular benefits of finerenone were observed particularly in patients with higher baseline blood pressure levels.

Structured PICO

Does finerenone lower blood pressure and do its cardiovascular benefits depend on baseline blood pressure or blood-pressure reduction in patients with mildly reduced or preserved ejection fraction heart failure?

P
Population
patients with mildly reduced or preserved ejection fraction heart failure
I
Intervention
finerenone
O
Outcome
blood pressure and cardiovascular benefits

This trial investigates the blood pressure-lowering effects of finerenone and their relationship to cardiovascular outcomes in patients with HFmrEF or HFpEF.

Abstract

This randomized clinical trial analyzes whether finerenone lowers blood pressure and whether its cardiovascular benefits in patients with mildly reduced or preserved ejection fraction heart failure depend on baseline blood pressure or blood-pressure reduction.

Expert Takes4 quotes

1/4

“This FINEARTS-HF analysis supports the use of finerenone to improve cardiovascular outcomes across a broad BP spectrum in HFmrEF/HFpEF.”

Medscape CardiologyView source
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Cite This Study

Ostrominski et al. (2026) studied this question. Finerenone was analyzed to assess if it lowers blood pressure and if its cardiovascular benefits in HFmrEF or HFpEF depend on baseline blood pressure or blood pressure reduction.

synapsesocial.com/papers/6a508d546eeac72a437a0e7fhttps://doi.org/10.1001/jamacardio.2026.2104
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