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March 6, 2025Journal of Nuclear Medicine11 citationsOpen Access

Comparison of 68GaGa-Fibroblast Activation Protein Inhibitor–04 and 18FFDG PET Imaging for Solitary Fibrous Tumor and Preliminary Application of FAP-Targeted Radiopharmaceutical Therapy

RWRongxi WangJWJiarou WangJXJialin Xiang

Key Result

[68Ga]Ga-FAPI-04 is a promising PET imaging agent for assessing solitary fibrous tumors, which exhibit high FAP expression that may serve as a potential therapeutic target.

Structured PICO

Does [68Ga]Ga-FAPI-04 PET imaging improve the assessment of solitary fibrous tumors compared to [18F]FDG PET imaging?

P
Population
Patients with Solitary Fibrous Tumor (SFT)
I
Intervention
[68Ga]Ga-Fibroblast Activation Protein Inhibitor-04 PET imaging
C
Comparator
[18F]FDG PET imaging
O
Outcome
Assessment of SFTssurrogate

[68Ga]Ga-FAPI-04 is a promising PET imaging agent and potential therapeutic target for solitary fibrous tumors.

Abstract

Ga]Ga-FAPI-04 may be a promising PET agent for the assessment of SFTs. Given the lack of effective treatments for advanced SFTs, high FAP expression in this type of tumor is expected to become a potential treatment target.

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Cite This Study

Wang et al. (2025) studied this question. [68Ga]Ga-FAPI-04 is a promising PET imaging agent for assessing solitary fibrous tumors, which exhibit high FAP expression that may serve as a potential therapeutic target.

synapsesocial.com/papers/6a5d26e0fb7682ce97c22f7chttps://doi.org/10.2967/jnumed.124.268258
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