Microwave ablation created significantly larger mean ablation zone diameters (3.32 cm vs 2.70 cm; P<0.001) and cross-sectional areas than radiofrequency ablation in a porcine lung model.
Does microwave ablation create larger and more circular ablation zones compared to radiofrequency ablation in a normal porcine lung model?
In a preclinical porcine model, microwave ablation created significantly larger and more circular ablation zones in lung tissue compared to equivalently sized radiofrequency ablation.
Absolute Event Rate: 3.32% vs 2.7%
p-value: p=<.001
PURPOSE: To compare the performance of equivalently sized radiofrequency and microwave ablation applicators in a normal porcine lung model. MATERIALS AND METHODS: All experiments were approved by an institutional animal care and use committee. A total of 18 ablations were performed in vivo in normal porcine lungs. By using computed tomographic (CT) fluoroscopic guidance, a 17-gauge cooled triaxial microwave antenna (n = 9) and a 17-gauge cooled radiofrequency (RF) electrode (n = 9) were placed percutaneously. Ablations were performed for 10 minutes by using either 125 W of microwave power or 200 W of RF power delivered with an impedance-based pulsing algorithm. CT images were acquired every minute during ablation to monitor growth. Animals were sacrificed after the procedure. Ablation zones were then excised and sectioned transverse to the applicator in 5-mm increments. Minimum and maximum diameter, cross-sectional area, length, and circularity were measured from gross specimens and CT images. Comparisons of each measurement were performed by using a mixed-effects model; P < .05 was considered to indicate a significant difference. RESULTS: Mean diameter (3.32 cm +/- 0.19 standard deviation vs 2.70 cm +/- 0.23, P < .001) was 25% larger with microwave ablation and mean cross-sectional area (8.25 cm(2) +/- 0.92 vs 5.45 cm(2) +/- 1.14, P < .001) was 50% larger with microwave ablation, compared with RF ablation. With microwave ablation, the zones of ablation were also significantly more circular in cross section (mean circularity, 0.90 +/- 0.06 vs 0.82 +/- 0.09; P < .05). One small pneumothorax was noted during RF ablation but stabilized without intervention. CONCLUSION: Microwave ablation with a 17-gauge high-power triaxial antenna creates larger and more circular zones of ablation than does a similarly sized RF applicator in a preclinical animal model. Microwave ablation may be a more effective treatment of lung tumors.
Brace et al. (2009) studied Normal porcine lung model (n=18). Microwave ablation vs. Radiofrequency ablation was evaluated on Mean diameter of ablation zone (p=<.001). Microwave ablation created significantly larger mean ablation zone diameters (3.32 cm vs 2.70 cm; P<0.001) and cross-sectional areas than radiofrequency ablation in a porcine lung model.