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May 13, 2009Organic Letters145 citations

Simple Conversion of Enamines to 2H-Azirines and Their Rearrangements under Thermal Conditions

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XLXiaoxun LiYDYunfei DuZLZhidan Liang

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Abstract

A variety of substituted enamine derivatives were first found to be conveniently converted to the corresponding 2H-azirines mediated by phenyliodine (III) diacetate (PIDA). The formed 2-aryl-2H-azirines could be applied in the synthesis of indole-3-carbonitriles or isoxazoles via thermal rearrangements.

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Li et al. (2009) studied this question.

synapsesocial.com/papers/6a5f68cc93a99557d97e745ahttps://doi.org/10.1021/ol9006663
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