Young patients with uncomplicated IDDM had 29% lower systemic arterial compliance compared with age-matched controls (0.46 vs. 0.65 arbitrary compliance units, P < 0.05).
Case-Control (n=55)
Does uncomplicated IDDM reduce systemic arterial compliance in young patients before the development of overt vascular disease?
Young patients with uncomplicated IDDM exhibit significantly reduced systemic arterial compliance compared to healthy controls, suggesting early vascular changes before overt disease.
Effect estimate: 29% lower
Absolute Event Rate: 0.46% vs 0.65%
p-value: p=< 0.05
Arterial elastic properties are altered with increasing age and in various disease states, including non-insulin-dependent diabetes mellitus (NIDDM). Whether young patients with insulin-dependent diabetes mellitus (IDDM) have reduced arterial compliance before developing endothelial dysfunction or overt micro- and macrovascular disease is unclear. Systemic arterial compliance and endothelium-dependent, flow-mediated vasodilation (FMD) was assessed in 25 individuals with uncomplicated IDDM (23 +/- 4 yr, 14 females and 11 males) and compared with 30 age-matched controls (15 females and 15 males). Arterial compliance was determined via simultaneous measurements of aortic blood flow and carotid arterial pressure. The relationship between arterial compliance and endothelial function (assessed by brachial artery FMD) was also examined. Arterial compliance was 29% lower in IDDM subjects compared with control subjects (0.46 +/- 0.05 vs. 0.65 +/- 0.07 arbitrary compliance units, P < 0.05). Blood pressure, lipid levels, and daily energy expenditure (a measure of physical activity levels) were not different between groups. Compliance in the IDDM group was not related to the integrity of endothelial vasodilator function, disease duration, or degree of glycemic control. Arterial compliance is reduced in young patients with IDDM before the development of overt micro- or macrovascular disease. Early assessment of arterial compliance may be useful in predicting the development of diabetic vascular complications.
Berry et al. (1999) conducted a case-control in Insulin-dependent diabetes mellitus (IDDM) (n=55). Insulin-dependent diabetes mellitus (IDDM) vs. Age-matched healthy controls was evaluated on Systemic arterial compliance (29% lower, p=< 0.05). Young patients with uncomplicated IDDM had 29% lower systemic arterial compliance compared with age-matched controls (0.46 vs. 0.65 arbitrary compliance units, P < 0.05).