Key points are not available for this paper at this time.
OBJECTIVE: Recent evidence suggests a strong association between triglyceride glucose-a body shape index (TyG-ABSI) and cardiovascular mortality. However, the association between TyG-ABSI and incident stroke has not been explored. Our study utilized a prospective cohort design to explore the potential association between TyG-ABSI and incident stroke within a Chinese population. METHODS: A total of 8,715 subjects from the China Health and Retirement Longitudinal Study were included in this analysis, categorized into stroke (n = 805) and non-stroke (n = 7,910) groups. To assess the association between TyG-ABSI and incident stroke, this study employed Cox proportional hazards regression, restricted cubic spline models, subgroup analyses, and sensitivity analyses. RESULTS: The mean age of participants was significantly higher in the stroke group (61.26 ± 8.42 years) compared to the non-stroke group (59.14 ± 9.27 years). Multivariate analysis revealed that higher TyG-ABSI was significantly associated with increased stroke risk, with an HR of 1.22 (95% CI: 1.09-1.37, P = 0.0004). Notably, this association between TyG-ABSI and incident stroke was non-linear, and a significant inflection point was identified at a TyG-ABSI of 6.42. The HR to the left and right of this inflection point were 2.44 (95%CI: 1.19-5.02, P = 0.0151) and 1.16 (95%CI: 1.02-1.31, P = 0.0239), respectively. Subgroup and sensitivity analyses further validated the robustness of the association between TyG-ABSI and incident stroke. CONCLUSION: Our analysis revealed a non-linear positive association between TyG-ABSI and incident stroke. These findings emphasize the necessity of incorporating TyG-ABSI monitoring into clinical practice to identify individuals at greater risk for stroke.
He et al. (2025) studied this question.