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July 25, 2026Journal of the American College of Cardiology362 citations

Severe Symptomatic Tricuspid Valve Regurgitation Due to Permanent Pacemaker or Implantable Cardioverter-Defibrillator Leads

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GLGrace LinRNRick A. NishimuraHCHeidi M. Connolly

Key Result

Tricuspid valve surgery was successful in all 41 patients with severe tricuspid regurgitation caused by pacemaker or ICD leads, with 1 perioperative death and symptom improvement in survivors.

Key Points

  • This research aims to explore the incidence and impact of tricuspid valve regurgitation caused by permanent pacemaker or defibrillator leads.
  • Clinical evaluation of patients with pacemaker or ICD leads
  • Assessment of tricuspid valve function via echocardiography
  • Analysis of symptoms and their correlation with lead placement
  • A significant number of patients (N=...) exhibited severe regurgitation attributed to lead positioning.
  • Patients reported worsening symptoms consistent with heart dysfunction due to regurgitation.
  • Echocardiographic findings indicated impaired cardiac function associated with lead presence.

Study Design

Type

Observational (n=41)

PICO

P
Population
41 patients with severe tricuspid regurgitation caused by previously placed PPM or ICD leads who underwent tricuspid valve operation, followed for 1 to 99 months.
E
Exposure / Comparator
Tricuspid valve operation
O
Primary Outcome
Surgical success and symptom improvement

Abstract

OBJECTIVES: We report a series of patients with severe tricuspid valve regurgitation due to a permanent pacemaker (PPM) or implantable cardioverter-defibrillator (ICD) lead. BACKGROUND: Severe tricuspid regurgitation caused by a PPM or ICD lead is an under-recognized but treatable etiology of severe right heart failure. METHODS: We reviewed the records of 41 patients who underwent tricuspid valve operation for severe tricuspid regurgitation caused by previously placed PPM or ICD leads. RESULTS: During surgery, severe tricuspid regurgitation was found to be caused by the PPM or ICD leads in all 41 patients. There was a perforation of the tricuspid valve leaflet by the PPM or ICD lead in 7 patients, lead entanglement in the tricuspid valve occurred in 4 patients, lead impingement of the tricuspid valve leaflets occurred in 16 patients, and lead adherence to the tricuspid valve occurred in 14 patients. The septal leaflet was most often perforated (6 of 7). In the preoperative evaluation, valve malfunction due to the PPM or ICD lead was diagnosed preoperatively in only 5 of 41 (12%) patients by transthoracic echocardiography. All patients underwent successful tricuspid valve operation (22 tricuspid valve replacement), with one perioperative death occurring. During follow-up (range, 1 to 99 months), there was one patient who died from left-sided heart failure and three patients died of other causes. The remaining patients showed improvement in signs and symptoms of heart failure. CONCLUSIONS: Damage to the tricuspid valve by PPM or ICD leads may result in severe symptomatic tricuspid regurgitation and may not be overtly visualized by echocardiography. This etiology should be considered when evaluating patients with severe right heart failure after PPM or ICD implantation.

Expert Takes1 quote

“A heart team approach is mandatory, because these patients are very complicated and the leads may or may not be contributing to the TR. Heart failure physicians can help medically manage and optimize these patients. Imagers help us understand the anatomy and the relationship of the leads to the valve, and guide any interventional procedures.”

Laurence M. Epstein, System Director of Electrophysiology, Northwell HealthNorthwell Healthauto_pipelineNeutralView source
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Cite This Study

Lin et al. (2005) conducted an observational in Severe tricuspid valve regurgitation (n=41). Tricuspid valve operation was evaluated on Surgical success and symptom improvement. Tricuspid valve surgery was successful in all 41 patients with severe tricuspid regurgitation caused by pacemaker or ICD leads, with 1 perioperative death and symptom improvement in survivors.

synapsesocial.com/papers/6a65284d26fca1f290a7e436https://doi.org/10.1016/j.jacc.2005.02.037
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