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April 1, 2003The Journal of Physiology

Acute shifts of baroreflex control of renal sympathetic nerve activity induced by treadmill exercise in rats

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Population

Wistar female rats chronically implanted with catheters for measurement of systemic arterial and central…

Comparison

Treadmill exercise vs Pre-exercise baseline

Design

Preclinical

Key result

Treadmill exercise shifted the Pa-RSNA baroreflex curve upward and to the right, significantly increasing response range, maximum response, maximum gain, and midpoint pressure (P<0.05).

Authors

KMKenju MikiMYMisa YoshimotoMTMomoko Tanimizu

Discussion

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Overview

Should not change practice; hypothesis-generating for exercise effects on sympathetic baroreflex control.

Structured PICO

P
Population
11 female Wistar rats chronically implanted with catheters and electrodes to evaluate baroreflex control during treadmill exercise.
I
Intervention
Treadmill exercise
C
Comparator
Pre-exercise baseline
O
Outcome
Baroreflex control of renal sympathetic nerve activity (RSNA) and heart rate (HR), including response range, gain, centering point, and minimum responsesurrogate

Main Result

p-value: p=<0.05

Treadmill exercise in rats induces an acute right-upward shift in baroreflex control of sympathetic nerve activity, which may stabilize arterial pressure during exercise and contribute to post-exercise hypotension upon cessation.

Cite This Study

Miki et al. (2003) studied this question. Treadmill exercise vs. Pre-exercise level was evaluated on Pa-RSNA baroreflex curve parameters (response range, maximum response, maximum gain, midpoint pressure) (p=<0.05). Treadmill exercise shifted the Pa-RSNA baroreflex curve upward and to the right, significantly increasing response range, maximum response, maximum gain, and midpoint pressure (P<0.05).

synapsesocial.com/papers/6a656b23d8f85b2777d78550https://doi.org/10.1111/j.1469-7793.2003.00313.x
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