Anti-hypertensive Single Pill Combinations were priced higher than the sum of their component Single Agent Pills by most manufacturers (5 of 6) in India's private sector.
Observational
Are anti-hypertensive Single Pill Combinations (SPCs) priced higher than equivalent Single Agent Pills (SAPs) in India's private health care sector?
Manufacturing costs and market forces do not present a barrier to implementing anti-hypertensive SPCs, as their prices could be lowered to match the combined price of component SAPs.
More than half of patients with hypertension require two or more medicines to control blood pressure. Combinations of anti-hypertensive medicines are available as Single Pill Combinations (SPCs) or Single Agent Pills (SAPs). SPCs of two or more anti-hypertensive medicines facilitate simpler dosing schedules, decrease pill burden, increase adherence to medicine, and simplify procurement and distribution. Despite this, equivalent combinations of separate pills (SAPs) are often prescribed instead of SPCs under the assumption that SAPs are priced lower. This study compared prices of anti-hypertensive SPCs and equivalent SAPs in the private health care sector of India. High sales volume anti-hypertensive SPCs and SAPs were selected from 2018 private sector pharmaceutical sales data. SPCs and SAPs price information was collected from online pharmacy websites between November 2019 and January 2020. Anti-hypertensive SPCs represent approximately 39.1% of India's private sector anti-hypertensive drug market. Multiple manufacturers produce the same top-selling SPCs, suggesting a viable and competitive market. A comparison of SPCs and SAPs across different manufacturers showed that the lowest prices of both SPCs and the sum of component SAPs were nearly identical across different manufacturers. An analysis of dual-drug SPCs and SAPs by the same manufacturer showed that most manufacturers (five of six) had priced their SPCs higher than SAPs. These observations suggest that the price of SPCs could be lowered to match the combined price of the component SAPs, and manufacturing costs and market forces do not present a barrier to the implementation of anti-hypertensive SPCs.
Negi et al. (2020) conducted an observational in Hypertension. Single Pill Combinations (SPCs) vs. Single Agent Pills (SAPs) was evaluated on Price comparison between SPCs and equivalent SAPs. Anti-hypertensive Single Pill Combinations were priced higher than the sum of their component Single Agent Pills by most manufacturers (5 of 6) in India's private sector.