Higher segmental epicardial adipose tissue volume was significantly associated with increasing luminal stenosis (severe 11.8 vs mild 8.2 cm3, P<0.001) and mixed plaque types (P=0.015).
Observational (n=43)
Is segmental epicardial adipose tissue volume associated with coronary plaque characteristics and severity in patients with stable angina?
Segmental peri-coronary epicardial adipose tissue volume is significantly associated with the extent and severity of coronary atherosclerosis, suggesting a role in plaque vulnerability.
p-value: p=<0.001
AIMS: Epicardial adipose tissue (EAT) has been proposed to modulate underlying coronary plaque features. The study aimed to determine the relation between segmental EAT (sEAT) volume, assessed by cardiac magnetic resonance (CMR), and underlying coronary plaque characteristics, as estimated by multidetector computed tomography (CT) (MDCT). METHODS AND RESULTS: The study included 32 male patients with stable angina pectoris and 11 age-matched healthy controls. For each CAD patient, sEAT volume around 8 coronary segments (3 in left anterior descending artery, 3 in right coronary artery, and 2 in left circumflex artery) was quantified by CMR. By MDCT, plaques in each coronary segment were characterized in terms of plaque volume, type, CT attenuation, and severity of luminal stenosis. Serum levels of adipokines were measured. Total EAT volume was significantly higher in CAD patients than in control group. Serum resistin showed significant correlation with EAT volume (r = 0.69, P 30 HU (10.5 vs. 8.2 mm(3), P < 0.001). CONCLUSION: Peri-coronary epicardial adipose tissue volume is significantly associated with the extent and severity of coronary atherosclerosis and may be a determinant of plaque vulnerability.
Hassan et al. (2015) conducted an observational in Stable angina pectoris (n=43). Segmental epicardial adipose tissue (sEAT) volume vs. Healthy controls / segments with less stenosis was evaluated on Relation between segmental EAT volume and underlying coronary plaque characteristics (luminal stenosis, plaque type, CT attenuation) (p=<0.001). Higher segmental epicardial adipose tissue volume was significantly associated with increasing luminal stenosis (severe 11.8 vs mild 8.2 cm3, P<0.001) and mixed plaque types (P=0.015).