Angiotensin(1-7) produced substantial natriuresis, diuresis, and increased glomerular filtration rate without affecting renal vascular resistance in the isolated rat kidney.
Does angiotensin(1-7) induce natriuresis and diuresis in an isolated rat kidney model?
Angiotensin(1-7) demonstrates significant natriuretic and diuretic effects in the isolated rat kidney, suggesting it participates in the renal effects of the renin-angiotensin system.
Evidence that angiotensin(1-7) (Ang(1-7)) is biologically active and can be synthesized by the kidney prompted us to examine its actions in the rat, isolated kidney. Ang(1-7) had three major effects producing, (1) a substantial natriuresis and diuresis, (2) an increase in urinary sodium concentration associated with a fall in potassium concentration and (3) an increase in glomerular filtration rate without affecting renal vascular resistance. Thus, Ang(1-7) may participate in the renal effects of the renin-angiotensin system.
DelliPizzi et al. (1994) studied this question. Angiotensin(1-7) was evaluated on Natriuresis, diuresis, urinary sodium concentration, and glomerular filtration rate. Angiotensin(1-7) produced substantial natriuresis, diuresis, and increased glomerular filtration rate without affecting renal vascular resistance in the isolated rat kidney.