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January 17, 2001Organic Letters62 citations

Enantioselective Rhodium(I)-Catalyzed Hydrogenation of Trifluoromethyl Ketones

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YKYoshichika KurokiYSYuko SakamakiKIKatsuhiko Iseki

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Abstract

figure: see text The asymmetric hydrogenation of trifluoromethyl ketones to yield chiral alpha-trifluoromethyl alcohols with enantiomeric excesses up to 98% was achieved in the presence of chiral rhodium-(amidephosphine-phosphinite) complexes.

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Cite This Study

Kuroki et al. (2001) studied this question.

synapsesocial.com/papers/6a6d1b40e36a167817dfdc1bhttps://doi.org/10.1021/ol006962s
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