November 15, 2021Journal of Cardiovascular Development and Disease131 citationsOpen Access
Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know?
Key Result
Cardiovascular autonomic dysfunction is common in post-acute sequelae of SARS-CoV-2 (PASC) and presents similarly to postural orthostatic tachycardia syndrome and inappropriate sinus tachycardia.
Structured PICO
P
Population
Patients with previous SARS-CoV-2 infection experiencing Post-acute sequelae of SARS-CoV-2 (PASC) or long COVID syndrome
This review highlights the prevalence of cardiovascular autonomic dysfunction in long COVID and outlines potential mechanisms and management strategies.
Abstract
Post-acute sequelae of SARS-CoV-2 (PASC), or long COVID syndrome, is emerging as a major health issue in patients with previous SARS-CoV-2 infection. Symptoms commonly experienced by patients include fatigue, palpitations, chest pain, dyspnea, reduced exercise tolerance, and "brain fog". Additionally, symptoms of orthostatic intolerance and syncope suggest the involvement of the autonomic nervous system. Signs of cardiovascular autonomic dysfunction appear to be common in PASC and are similar to those observed in postural orthostatic tachycardia syndrome and inappropriate sinus tachycardia. In this review, we report on the epidemiology of PASC, discuss current evidence and possible mechanisms underpinning the dysregulation of the autonomic nervous system, and suggest nonpharmacological and pharmacological interventions to treat and relieve symptoms of PASC-associated dysautonomia.
Cite This Study
Bisaccia et al. (2021) conducted a review in Post-acute sequelae of SARS-CoV-2 (PASC) / long COVID syndrome. Cardiovascular autonomic dysfunction is common in post-acute sequelae of SARS-CoV-2 (PASC) and presents similarly to postural orthostatic tachycardia syndrome and inappropriate sinus tachycardia.