A stress hyperglycemia ratio >1 on hospital admission significantly increased the risk of rehospitalization for chest pain at 1 year in patients with INOCA (HR 2.820).
Cohort (n=2,874)
No
Does a stress hyperglycemia ratio > 1 on hospital admission increase the risk of rehospitalization for chest pain in patients with INOCA?
An elevated stress hyperglycemia ratio (>1) on hospital admission is a significant and independent predictor of 1-year rehospitalization for chest pain in patients with INOCA.
Hazard Ratio: 2.82 (95% CI 2.196–3.622)
p-value: p=<0.001
OBJECTIVE: Ischemia with nonobstructive coronary arteries (INOCA) is a prevailing finding in patients with angina. However, the main factors underlying the risk of being rehospitalized for chest pain in patients with INOCA remain mostly unknown. RESEARCH DESIGN AND METHODS: We evaluated INOCA patients referred to the "Casa di Cura Montevergine" in Mercogliano (Avellino), Italy, from January 2016 to January 2021 for percutaneous coronary intervention (PCI). In these subjects, we assessed the impact of the stress hyperglycemia ratio (SHR), defined as the ratio of mmol/L blood glucose and % HbA1c, on the risk of rehospitalization for chest pain. RESULTS: A total of 2,874 patients with INOCA successfully completed the study. At the 1-year follow-up, the risk of rehospitalization for chest pain was significantly higher (P 1 compared to patients with SHR ≤1. These findings were confirmed by multivariable analyses (adjusting for potential confounders, including age, BMI, blood pressure, heart rate, chronic kidney disease, and cholesterol), propensity score matching, and inverse probability of treatment weighting. CONCLUSIONS: Our data indicate, to our knowledge for the first time, that SHR on hospital admission significantly and independently increases the risk of rehospitalization for chest pain in INOCA patients.
Mone et al. (2022) conducted a cohort in Ischemia with nonobstructive coronary arteries (INOCA) (n=2,874). Stress hyperglycemia ratio (SHR) > 1 vs. Stress hyperglycemia ratio (SHR) ≤ 1 was evaluated on Rehospitalization for chest pain (HR 2.820, 95% CI 2.196-3.622, p=<0.001). A stress hyperglycemia ratio >1 on hospital admission significantly increased the risk of rehospitalization for chest pain at 1 year in patients with INOCA (HR 2.820).