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September 18, 1970Science1,601 citations

Polypeptide with Broad Biological Activity: Isolation from Small Intestine

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SSSami I. SaidVMViktor Mutt

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Abstract

A polypeptide, which has potent and diverse biological action-including systemic vasodilation, hypotension, increased cardiac output, respiratory stimulation, and hyperglycemia-was isolated from the small intestine of the hog. The peptide has 28 amino acid residues and is chemically distinct from the kinins, "substance P," glucagon, and secretin.

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Cite This Study

Said et al. (1970) studied this question.

synapsesocial.com/papers/6a6f978626a7f98052dc3a74https://doi.org/10.1126/science.169.3951.1217
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