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April 1, 1981AJP Heart and Circulatory Physiology32 citations

Decreased total venous capacity in Goldblatt hypertensive rats

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Population

Conscious rats evaluated during the early, intermediate, and chronic phases of one-kidney, one-clip…

Comparison

One-kidney, one-clip Goldblatt hypertension… vs One-kidney sham groups

Design

Preclinical

Follow-up

3, 14, and 28 days postclipping

Authors

JYJ. YamamotoNTN. C. TrippodoAMA. A. MacPhee

Discussion

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Overview

In a rat model of Goldblatt hypertension, venous constriction is increased and whole-body venous capacity is decreased across all phases of hypertension without changes in total blood volume.

Structured PICO

P
Population
Conscious rats evaluated during the early, intermediate, and chronic phases of one-kidney, one-clip Goldblatt hypertension
I
Intervention
One-kidney, one-clip Goldblatt hypertension induction
C
Comparator
One-kidney sham groups
O
Outcome
Mean circulatory filling pressure (MCFP) and total blood volume (BV)surrogate

In a rat model of Goldblatt hypertension, venous constriction is increased and whole-body venous capacity is decreased across all phases of hypertension without changes in total blood volume.

Cite This Study

Yamamoto et al. (1981) studied this question.

synapsesocial.com/papers/6a70abb2e36a167817e27e68https://doi.org/10.1152/ajpheart.1981.240.4.h487
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