In young post-myocardial infarction patients, dense triglyceride-rich LDL particles and small cholesteryl ester-rich VLDL particles are associated with the severity of coronary artery disease.
BACKGROUND: Hypertriglyceridemia is a common metabolic disturbance in men 1.040 kg/L) was strongly associated with both coronary scores. Compositional analysis of the smallest VLDL particles (VLDL3) and IDL revealed a correlation between the number of cholesteryl ester molecules in small VLDL and global coronary atherosclerosis in hypertriglyceridemic patients. CONCLUSIONS: Global coronary atherosclerosis and distinct stenoses in young postinfarction patients are associated with the number of apolipoprotein B-containing particles in plasma and the concentration of LDL triglyceride. Specifically, dense triglyceride-rich LDL particles and, in hypertriglyceridemic patients, small cholesteryl ester-rich VLDL particles relate to coronary artery disease severity.
Tornvall et al. (1993) studied this question.
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