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August 15, 1981Acta Crystallographica Section B17 citations

Structure determination of tolbutamide

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KNK. A. NirmalaDGD. S. Sake Gowda

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Abstract

N-​(Butylamino)​carbonyl​-​4-​methylbenzenesulfonamide, is an antidiabetic drug which crystd. in orthorhombic space group Pn21a, with a 20.16(2)​, b 9.05(1)​, c 7.85(1) Å; Z = 4, d.(exptl.) = 1.24 and d.(calcd.) = 1.25 for Z = 4. The structure was solved by the Patterson search method and refined to R = 0.083 for 615 visually measured reflections. At. parameters are given. The structure is stabilized by H bonding between the polar ground and van der Waals interactions between the nonpolar groups. Of the three H bonds, two are weakly as they are bifurcated.

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Nirmala et al. (1981) studied this question.

synapsesocial.com/papers/6a723baa35aa2c282ce326dehttps://doi.org/10.1107/s056774088100664x
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