April 14, 1994New England Journal of Medicine132 citations
The Endothelium and Cardiovascular Disease -- A Complex Relation
View Full Paper
Key Points
- This research aims to understand how changes in the endothelium contribute to cardiovascular disease.
- Review of existing literature on endothelial changes in cardiovascular conditions.
- Analysis of vascular abnormalities linked to diseases like angina and myocardial infarction.
- Identified key factors such as vasoconstriction and blood cell interactions that influence disease progression.
- Found that abnormal endothelium plays a major role in the development of various cardiovascular diseases.
Abstract
Cardiovascular disease accounts for considerable mortality and morbidity in Western countries. Most of the common forms of cardiovascular disease, such as atherosclerosis, are caused by functional and structural changes in the blood-vessel wall. These changes include abnormal vasoconstriction, enhanced interaction of blood cells with the vessel wall, activation of coagulation mechanisms, and migration and proliferation of vascular smooth-muscle cells13. Depending on the stage and location of the disease, one or more of these factors predominate. These vascular abnormalities have an important role in the pathogenesis of angina pectoris, myocardial infarction, stroke, and vascular forms of renal failure.A . . .
Cite This Study
Thomas F. Lüscher (1994) studied this question.