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August 11, 2026Journal of Cardiac Failure4 citationsOpen Access

Ascertaining Death Events in a Pragmatic Clinical Trial: Insights From the TRANSFORM-HF Trial

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EEEric L. EisensteinSSShelly SappTHTina Harding

Key Points

  • The research aims to determine how death events are recorded in a pragmatic clinical trial focused on heart failure.
  • Conducted as part of the TRANSFORM-HF trial
  • Analyzed death events within the framework of pragmatic clinical methodology
  • Utilized a randomized trial design encompassing diverse heart failure outcomes
  • Identified specific criteria for ascertaining death events
  • Highlighted variations in reporting methods among centers
  • Provided recommendations for standardized death event documentation
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Cite This Study

Eisenstein et al. (2022) studied this question.

synapsesocial.com/papers/6a7b6fc74aa654994ddc2d31https://doi.org/10.1016/j.cardfail.2022.01.020
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lost to Follow‐Up in Pragmatic Trials With Remote Follow‐Up: Insights From CONNECT‐HF and TRANSFORM‐HF2026
  2. 2Biomarker, Functional Status, and Quality-of-Life Trajectories Before Modes of Death in Heart Failure2026 · 2 citations
  3. 3Development and Evaluation of a Multisource Approach to Extend Mortality Follow-Up for Older Adults With Advanced Cancer Enrolled in Randomized Trials2024 · 4 citations
  4. 4Why do People with Heart Failure Die? Rationale and Design of the RHYTHM-HF Study2025 · 1 citations
  5. 5Seeking Ways to Address Non-Cardiovascular Death in Patients with Heart Failure2024