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A third type of hemophilia characterized by a deficiency in a plasma thromboplastin factor other than anti-hemophilic globulin and plasma thromboplastin component (PTC) has been identified in 3 patients in one family, a maternal uncle and 2 nieces. 2. These patients reveal a mild hemorrhagic disease, and their clotting times are only moderately prolonged. 3. This newly described clotting factor, designated as plasma thromboplastin antecedent (PTA) is present in BaSO4-treated normal plasma and normal serum.
Rosenthal et al. (1953) studied this question.