Comorbid acute kidney injury in inpatients with acute myocardial infarction was associated with significantly higher in-hospital mortality (7.6% vs 0.9%; OR 4.64).
Cross-Sectional (n=77,585)
Yes
Does comorbid acute kidney injury increase in-hospital mortality in adult inpatients with acute myocardial infarction?
Comorbid acute kidney injury in patients hospitalized for acute myocardial infarction is associated with a significantly increased risk of in-hospital mortality.
Odds Ratio: 4.64 (95% CI 4.06–5.31)
Absolute Event Rate: 7.6% vs 0.9%
p-value: p=<0.001
Objective To delineate the differences in demographic characteristics and hospitalization outcomes in patients with acute myocardial infarction by comorbid acute kidney injury (AKI) and to explore the risk factors for in-hospital mortality due to AKI in acute myocardial infarction (AMI) inpatients. Methods We conducted a retrospective cross-sectional study using a nationwide inpatient sample and included 77,585 adult inpatients with AMI and further divided by the presence of a co-diagnosis of AKI. A logistic regression model was used to evaluate the odds ratio (OR) of the association between in-hospital mortality and AKI and other comorbidities. Results The prevalence of AKI in AMI inpatients during hospitalization was 11.69%. Among AMI inpatients with AKI, it was prevalent in males (73.9%) and whites (48.8%). Patients with AKI had a higher prevalence of complicated comorbid hypertension (58.7%), diabetes with complications (34.8%), cardiogenic shock (17.4%), and drug abuse (12.3%). Male patients had lower odds of in-hospital mortality (OR 0.69; 95% Cl 0.61-0.79) compared to females. Hispanics had a higher association with mortality (OR 1.45; 95% Cl 1.21-1.74) than whites and other races/ethnicities. Patients who developed cardiogenic shock were at 17 times higher odds of in-hospital mortality (OR 17.25; 95% CI 15.14-19.67), followed by AKI (OR 4.64; 95% CI 4.06-5.31), and alcohol abuse (OR 1.29; 95% CI 1.03-1.64). The in-hospital mortality rate among AMI inpatients with AKI (7.6%) was significantly higher compared to that seen in the non-AKI cohort (0.9%). Conclusion AMI inpatients with AKI during hospitalization was prevalent in males and whites. Among the demographic risk factors, females and Hispanics had a higher likelihood of in-hospital mortality during the inpatient management of AMI. Cardiogenic shock and AKI increased the odds of in-hospital mortality compared to other comorbidities in AMI inpatients.
Kaur et al. (2022) conducted a cross-sectional in Acute myocardial infarction (n=77,585). Acute kidney injury vs. No acute kidney injury was evaluated on In-hospital mortality (OR 4.64, 95% CI 4.06-5.31, p=<0.001). Comorbid acute kidney injury in inpatients with acute myocardial infarction was associated with significantly higher in-hospital mortality (7.6% vs 0.9%; OR 4.64).