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Synapse
October 31, 201355 citations

Role of Inflammation in Initiation and Perpetuation of Atrial Fibrillation: A Systematic Review of the Published Data.

KPK. Phillips

Key Result

Inflammation is strongly associated with the initiation and perpetuation of atrial fibrillation, though its causal role and the clinical utility of anti-inflammatory therapies remain unclear.

Study Design

Type

Systematic Review

Structured PICO

What is the role of inflammation in the initiation and perpetuation of atrial fibrillation?

P
Population
Patients with or at risk of atrial fibrillation
E
Exposure
Inflammation
O
Outcome
Initiation and perpetuation of atrial fibrillation

This systematic review highlights the strong association and possible causal role of inflammation in the initiation and perpetuation of atrial fibrillation.

Limitations

  • Whether inflammation is a causal pathway for AF or simply an epiphenomenon remains unclear.
  • Routine measurement of inflammatory biomarkers and empiric use of anti-inflammatory therapies cannot currently be generalized to the wider AF population.

Abstract

Inflammation has emerged as being strongly associated with AF initiation and perpetuation, including being implicated as a possible causal factor. Its role needs further elucidation to assist with the optimal prevention and treatment of AF using an individualized strategy. In the present review article the current published data linking inflammation to AF is summarized.

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Cite This Study

K. Phillips (2013) conducted a systematic review in Atrial Fibrillation. Inflammation was evaluated. Inflammation is strongly associated with the initiation and perpetuation of atrial fibrillation, though its causal role and the clinical utility of anti-inflammatory therapies remain unclear.

synapsesocial.com/papers/6a7bcf681f8f1eb7b8ed34c1https://doi.org/10.4022/jafib.935
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