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June 23, 2021New England Journal of Medicine1,228 citationsOpen Access

Acquired Resistance to KRAS G12C Inhibition in Cancer

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Abstract

BACKGROUND: ). The mechanisms of acquired resistance to these therapies are currently unknown. METHODS: inhibitors. RESULTS: inhibitors. CONCLUSIONS: inhibitors, and new therapeutic strategies are required to delay and overcome this drug resistance in patients with cancer. (Funded by Mirati Therapeutics and others; ClinicalTrials.gov number, NCT03785249.).

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A 2021 study studied this question.

synapsesocial.com/papers/6a7cdefe6d67ce102e8d1a6ehttps://doi.org/10.1056/nejmoa2105281
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