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Adult hamsters immunized with SV40 or polyoma virus were challenged with graded doses of virus-free polyoma or SV40 tumor cells. Animals immunized with SV40 virus were resistant to a small inoculum of SV40 tumor cells, and animals immunized with polyoma virus were resistant to a small inoculum of polyoma tumor cells. There was no cross protection between polyoma virus immunization and SV40 tumor cells or between SV40 virus immunization and polyoma tumor cells, even at the minimum cell dose required to give tumors in all the animals.
Vittorio Defendi (1963) studied this question.