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August 13, 2026The American Journal of Sports Medicine0 citationsOpen Access

Meniscal Allograft Transplantation Failure Is Associated With Female Sex: A 15-Year Survival Analysis

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YPYunseo Linda ParkAWAnja M. WackerleCJCharles Jiang

Key Points

  • This study aims to evaluate the long-term survivorship of meniscal allografts and the factors associated with graft failure, specifically focusing on sex differences.
  • Cohort study conducted at a single institution from 1993 to 2020.
  • Excluded individuals with less than 5 years of follow-up and severe cartilage lesions.
  • Statistical analyses included chi-square tests, Mann Whitney U tests, t tests, and Kaplan-Meier survival analysis.
  • The 10-year graft survival rate was 84%, declining to 76% at 15 years and 52% at 25 years.
  • Female sex emerged as a significant predictor of graft failure after adjusting for age and cartilage grade (P = .04).
  • Clinical failures occurred in 32 patients (40%), which were not associated with graft failures (P = .20).

Abstract

Background: While short- and midterm outcomes after meniscal allograft transplantation (MAT) are well documented, there is a paucity of data regarding long-term graft survival. Purpose: To assess mid- to long-term graft survivorship and patient-reported outcomes (PROs) after MAT. Study Design: Cohort study; Level of evidence, 3. Methods: All patients who underwent MAT with bone block or soft tissue fixation between 1993 and 2020 at a single institution were identified. Individuals with .05). However, after adjusting for age and cartilage grade in the MAT compartment, female sex became a significant predictor for graft failure ( P = .04). Clinical failures occurred in 32 patients (40%) and were not associated with graft failures ( P = .20). PROs were not significantly different between male and female patients ( P > .05). Conclusion: The MAT survival rate was 84% at 10 years, with a gradual decline to 76% at 15 years, 69% at 20 years, and 52% at 25 years. After adjusting for age and presence of cartilage lesion, female sex emerged as a predictor of graft failure. These findings highlight the importance of careful patient selection and counseling regarding long-term expectations after MAT.

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Cite This Study

Park et al. (2026) studied this question.

synapsesocial.com/papers/6a7d768a2b0e0cff3f63fe9ehttps://doi.org/10.1177/03635465261470172
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