Does temporary ventricular pacing control prenylamine-induced ventricular arrhythmias?
Prenylamine can cause life-threatening QT prolongation and ventricular arrhythmias, which can be managed with drug cessation and temporary ventricular pacing.
We describe eight patients treated for angina with prenylamine who developed life-threatening ventricular arrhythmias after QT interval prolongation. When prenylamine administration was stopped QT interval shortened to within normal values, while the ventricular arrhythmias were controlled by a temporary ventricular pacemaker and disappeared after several days. We stress the importance of surveillance of the QT interval and ventricular arrhythmias in patients receiving long-term treatment with prenylamine.
Grenadier et al. (1980) studied this question.