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August 13, 1976Science581 citations

Benzo a pyrene Diol Epoxides as Intermediates in Nucleic Acid Binding in Vitro and in Vivo

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IWI. Bernard WeinsteinAJAlan M. JeffreyKJK. W. Jennette

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Abstract

Evidence has been obtained that a specific isomer of a diol epoxide derivative of benzo(a)pyrene, (+/-)-7 beta,8alpha-dihydroxy-9alpha, 10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene, is an intermediate in the binding of benzo(a)pyrene to RNA in cultured bovine bronchial mucosa. An adduct is formed between position 10 of this derivative and the 2-amino group of guanine.

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Cite This Study

Weinstein et al. (1976) studied this question.

synapsesocial.com/papers/6a83d3de53408ed95e4d886dhttps://doi.org/10.1126/science.959820
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