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July 15, 2001Journal of Virology89 citationsOpen Access

Interleukin-12 (IL-12) and IL-18 Are Important in Innate Defense against Genital Herpes Simplex Virus Type 2 Infection in Mice but Are Not Required for the Development of Acquired Gamma Interferon-Mediated Protective Immunity

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AHAli M. HarandiBSBo SvennerholmJHJan Holmgren

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Abstract

Using a combination of gene-targeted mice and neutralizing antibodies, we showed that interleukin-12 (IL-12) and IL-18 are important in the innate control of genital herpes simplex virus type 2 infection but were not found to be critical, either singly or in combination, for the development of a protective gamma interferon-mediated immune response.

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Harandi et al. (2001) studied this question.

synapsesocial.com/papers/6a851a780771a786ab54dfebhttps://doi.org/10.1128/jvi.75.14.6705-6709.2001
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