Catheter ablation in end-stage heart failure significantly reduced persistent AF to 34.8% at 12 months (p=0.0001 vs baseline) and improved LVEF from 29.2% to 39.1% (p<0.001).
RCT (n=194)
randomized
Does catheter ablation reduce atrial fibrillation burden and improve ventricular function in patients with end-stage heart failure and atrial fibrillation?
Catheter ablation in patients with end-stage heart failure and atrial fibrillation significantly reduces AF burden and improves left ventricular ejection fraction.
p-value: p=0.0001
AIMS: The CASTLE-HTx trial showed the benefit of atrial fibrillation (AF) ablation compared to medical therapy in decreasing mortality, need for left ventricular assist device implantation or heart transplantation (HTx) in patients with end-stage heart failure (HF). Herein we describe the effects of catheter ablation on AF burden, arrhythmia recurrences, and ventricular function in end-stage HF. METHODS AND RESULTS: The CASTLE-HTx protocol randomized 194 patients in end-stage HF with AF to catheter ablation and medical therapy or medical therapy alone. AF burden, left ventricular ejection fraction (LVEF), and type of AF were assessed at baseline and at each follow-up visit. Overall, 97 patients received ablation; 66 patients (68%) underwent pulmonary vein isolation (PVI) and 31 patients (32%) were treated with PVI and additional ablation. Electroanatomic mapping showed the extent of left atrial low voltage (cardiomyopathy) >10% in 31 (31.9%) patients. At 12 months post-ablation, persistent AF was present in 31/89 patients (34.8%), which was significantly less frequent compared to baseline (p = 0.0001). Median AF burden reduction was 36.3 (interquartile range 13.6-63.3) percentage points at 12 months and LVEF improved from 29.2 ± 6.2% to 39.1 ± 8.3% (p < 0.001) following ablation. AF burden reduction <50% was significantly associated with LVEF improvement ≥5% at 12 months after ablation (p = 0.017). CONCLUSION: Atrial fibrillation ablation in end-stage HF leads to a substantial decrease in AF burden, a regression from persistent to paroxysmal AF and notably improved LVEF. Favourable ablation outcomes were observed in patients regardless of the presence or absence of signs indicating left atrial cardiomyopathy.
Sciacca et al. (2024) conducted an RCT in End-stage heart failure with atrial fibrillation (n=194). Catheter ablation vs. Medical therapy alone was evaluated on Persistent AF at 12 months post-ablation (p=0.0001). Catheter ablation in end-stage heart failure significantly reduced persistent AF to 34.8% at 12 months (p=0.0001 vs baseline) and improved LVEF from 29.2% to 39.1% (p<0.001).