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December 21, 2010Proceedings of the National Academy of Sciences24 citationsOpen Access

Essential “ankle” in the myosin lever arm

OPOlena PylypenkoAHAnne Houdusse

Key Result

A newly identified 'ankle' joint in the myosin lever arm provides structural insights into how strain promotes the attachment of the second myosin head to actin during isometric contraction.

PICO

P
Population
Muscle contraction and myosin structure

Limitations

  • Current resolution of EM studies is too low to reveal whether the two LCD adopt different conformations in the off state.
  • Additional structural studies are necessary to depict whether the phosphorylated serine fits within the RLC N-lobe.

Abstract

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.

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Cite This Study

Pylypenko et al. (2010) conducted an editorial in Muscle contraction and myosin structure. A newly identified 'ankle' joint in the myosin lever arm provides structural insights into how strain promotes the attachment of the second myosin head to actin during isometric contraction.

synapsesocial.com/papers/6a86dab77fdf9298f89eb8e2https://doi.org/10.1073/pnas.1017676108
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