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The intratypic serodifferentiation test of types 1 and 2 polioviruses was investigated after Wecker's method. Variables in the test were examined extensively with type 1 polioviruses; these included animals to be immunized, immunization schedules, time of bleeding, temperatures of incubation for the test and criterion of the evaluation of the results obtained. It was proved that the modified Wecker test was applicable to the differentiation of Sabin vaccine-related types 1 and 2 poliovirus strains from wild poliovirus isolated in Japan before the mass vaccination with Sabin vaccine in 1961. It was confirmed that the vaccine-related strains showed antigenic drift from the original strains during human passages. Several problems concerning the serological differentiaton of polioviruses are presented and discussed.
Kitahara et al. (1967) studied this question.
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