Standard decongestion therapy in patients with HFrEF and acute decompensated heart failure significantly reduced the venous impedance index from a median of 1.0 at admission to 0.59 at discharge.
Observational (n=35)
No
Does standard decongestion therapy improve intrarenal Doppler ultrasonographic parameters of renal venous congestion in patients with HFrEF and ADHF?
Standard decongestion therapy in ADHF patients with HFrEF significantly improves Doppler sonographic parameters of renal venous congestion and reduces albuminuria.
Absolute Event Rate: 0.59% vs 1%
p-value: p=<0.01
OBJECTIVES: Renal venous congestion due to backward heart failure leads to disturbance of renal function in acute decompensated heart failure (ADHF). Whether decongestion strategies have an impact on renal venous congestion is unknown. Objective was to evaluate changes in intrarenal hemodynamics using intrarenal Doppler ultrasonography (IRD) in patients with heart failure with reduced ejection fraction (HFrEF) and ADHF undergoing recompensation. METHODS: Prospective observational study in patients with left ventricular ejection fraction (LV-EF) ≤ 35% hospitalized due to ADHF. IRD measurement was performed within the first 48 h of hospitalisation and before discharge. Decongestion strategies were based on clinical judgement according to heart failure guidelines. IRD was used to assess intrarenal venous flow (IRVF) pattern, venous impedance index (VII) and resistance index (RI). Laboratory analyses included plasma creatinine, eGFR and albuminuria. RESULTS: A number of 35 patients with ADHF and LV-EF ≤ 35% were included into the study. IRD could be performed in 30 patients at inclusion and discharge. At discharge, there was a significant reduction of VII from a median of 1.0 (0.86-1.0) to 0.59 (0.26-1.0) (p < 0.01) as well as improvement of IRVF pattern categories (p < 0.05) compared to inclusion. Albuminuria was significantly reduced from a median of 78 mg/g creatinine (39-238) to 29 mg/g creatinine (16-127) (p = 0.02) and proportion of patients with normoalbuminuria increased (p = 0.01). Plasma creatinine and RI remained unchanged (p = 0.73; p = 0.43). DISCUSSION: This is the first study showing an effect of standard ADHF therapy on parameters of renal venous congestion in patients with HFrEF and ADHF. Doppler sonographic evaluation of renal venous congestion might provide additional information to guide decongestion strategies in patients with ADHF.
Wallbach et al. (2023) conducted an observational in Heart failure with reduced ejection fraction (HFrEF) and acute decompensated heart failure (ADHF) (n=35). Standard ADHF decongestion therapy vs. Baseline (at admission) was evaluated on Venous impedance index (VII) (p=<0.01). Standard decongestion therapy in patients with HFrEF and acute decompensated heart failure significantly reduced the venous impedance index from a median of 1.0 at admission to 0.59 at discharge.