Is 1-hour post-load hyperglycemia during a 75g OGTT associated with increased carotid intima-media thickness in subjects evaluated for impaired glucose tolerance?
Early post-load hyperglycemia at 60 minutes during an OGTT is a significant independent predictor of increased carotid intima-media thickness, suggesting its utility as a novel marker for atherosclerosis risk.
Postprandial hyperglycemia is considered as a risk factor of cardiovascular disease. We hypothesized that early post-load hyperglycemia might be more useful surrogate marker to assess atherosclerosis than plasma glucose (PG) level at 120 minutes because the peak of post-load glucose by 75gOGTT is usually shown at 60 minutes. 75gOGTT and carotid echography were investigated in 108 subjects who visited our hospital to examine impaired glucose tolerance. The association of post-load plasma glucose and insulin levels with intima-media thickness (IMT) was examined. Simple correlation analyses showed that fasting PG (FPG) (r=0.26, p=0.013), PG60 (r=0.40, p 1.1mm) were 188 and 101 mg/dL, respectively (p<0.01). These findings show that early post-load hyperglycemia, particularly PG60 is a novel risk factor of atherosclerosis and useful to assess it.
Tanaka et al. (2014) studied this question.