The ADIPOR2 polymorphism rs767870 was significantly associated with an increased risk of type 2 diabetes in the French population (adjusted OR 1.25; 95% CI 1.07-1.45; P=0.0051).
Case-Control (n=2,876)
Do sequence variations in ADIPOR1 and ADIPOR2 genes contribute to the genetic risk for type 2 diabetes in the Caucasian population?
Variants in the ADIPOR2 gene, specifically rs767870, have a modest contribution to the genetic risk for type 2 diabetes in the French Caucasian population.
Odds Ratio: 1.25 (95% CI 1.07–1.45)
p-value: p=0.0051
Adiponectin is a metabolic link between adipose tissue and insulin action, mediating part of obesity-associated insulin resistance and type 2 diabetes. Two adiponectin receptors have been identified, and we investigated whether sequence variations in adiponectin receptor 1 (ADIPOR1) and adiponectin receptor 2 (ADIPOR2) genes could contribute to the genetic risk for type 2 diabetes in a case-control study of 1,498 Caucasian subjects. We sequenced the putative functional regions of the two genes in 48 subjects and selected single nucleotide polymorphisms (SNPs) from the public database. Five SNPs in ADIPOR1 and 12 in ADIPOR2 were tested for association with type 2 diabetes. No SNP of ADIPOR1 showed association in any of the samples from the French population. In contrast, three SNPs of ADIPOR2 showed nominal evidence for association with type 2 diabetes before correction for multiple testing (odds ratio OR 1.29-1.37, P = 0.034-0.014); only rs767870, located in intron 6, was replicated in an additional diabetes dataset (n = 636, OR 1.29, P = 0.020) with significant allelic association from the overall meta-analysis of 2,876 subjects (adjusted OR 1.25 95% CI 1.07-1.45, P = 0.0051). In conclusion, our data suggest a modest contribution of ADIPOR2 variants in diabetes risk in the French population.
Vaxillaire et al. (2006) conducted a case-control in Type 2 diabetes (n=2,876). ADIPOR2 polymorphism rs767870 vs. Absence of the polymorphism was evaluated on Association with type 2 diabetes (OR 1.25, 95% CI 1.07-1.45, p=0.0051). The ADIPOR2 polymorphism rs767870 was significantly associated with an increased risk of type 2 diabetes in the French population (adjusted OR 1.25; 95% CI 1.07-1.45; P=0.0051).