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June 5, 1967JAMA51 citations

Early Surgical Treatment of Valvular Endocarditis

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BWBenson R. Wilcox

Key Points

  • To report the clinical outcomes of early surgical valve replacement prior to completing standard antibiotic courses in patients with severe, complicated bacterial endocarditis.
  • Case series evaluating three patients (N=3) with acute valvular destruction caused by bacterial endocarditis.
  • Operative valve replacement was performed prior to the completion of conventional prolonged antibiotic therapy due to hemodynamic collapse (n=2) or antimicrobial drug resistance (n=1).
  • All three patients recovered successfully following early valve replacement, showing no post-surgical evidence of persistent infection or congestive heart failure.
  • One patient subsequently underwent a successful left pneumonectomy for lung carcinoma six weeks after valve replacement.

Abstract

Three patients with valvular destruction secondary to bacterial endocarditis were treated by early valvular replacement. Operative intervention prior to completion of the conventional prolonged course of antibiotic therapy was necessitated by hemodynamic collapse in two patients and by drug resistance in a third patient. Six weeks after valve replacement in the patient in case 1, he successfully underwent left pneumonectomy for carcinoma of the lung. Following surgery, the three patients are doing well, with no evidence of infection or congestive heart failure.

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Cite This Study

Benson R. Wilcox (1967) studied this question.

synapsesocial.com/papers/6a8d0d68b6a5e72a852fe128https://doi.org/10.1001/jama.1967.03120230072008
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