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Pre- and postvaccination sera from individuals who had been vaccinated with live Jeryl-Lynn vaccine were assayed for mumps antibodies by using serum neutralization (NT), enzymed-linked immunosorbent assay (ELISA), hemolysis-in gel (HIG), hemagglutination inhibition (HI) and complement fixation (CF) techniques. ELISA was found to be equally specific and somewhat more sensitive than NT. HIG was less sensitive than either of these two and, with some specimens, less specific. However, it was more sensitive than HI. CF gave several low positive readings which were interpreted as false positive since they were found in prevaccination sera and other tests failed to detect antibodies in these samples. The ELISA mumps test can be used in place of the more expensive and time consuming neutralization test for screening epidemiology, documenting immunity and establishing the serological diagnosis.
Leinikki et al. (1979) studied this question.