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To determine the effect of exercise on the in vivo formation of circulating platelet aggregates in patients with severe coronary artery disease (CAD), platelet aggregate ratios (PAR) (normal 0.8-1.1)were measured immediately before and after treadmill exercise and 30 minutes after exercise in 17 CAD patients (group 1, mean age 55 years), 12 age-matched normal subjects (group 2), and 13 young normals (mean age 27 years, group 3).Coronary patients had lower resting PAR than group 3 (0.79 ± 0.05 vs 0.98 ± 0.03; p 0.05 vs CAD and group 3).Immediately after exercise, group I PAR declined from 0.79 i 0.05 to 0.53 ± 0.04 (p 0.05; both p 0.05; both p 0.05) from resting values without aspirin.The exercise-induced decline in PAR was attenuated by aspirin: without aspirin, 0.73 ± 0.02 preexercise to 0.54 ± 0.04 postexercise; with aspirin, 0.73 ± 0.03 to 0.82 ± 0.03 (p < 0.05 vs no aspirin).These data indicate that platelet aggregation occurs with exercise in CAD.In addition, these data suggest that aspirin exerts a significant inhibitory effect on exercise-induced platelet aggregation in CAD patients.
Kumpuris et al. (1980) studied this question.