Does intravenous ICI 50,172 alter haemodynamic responses to exercise in patients with hypertension?
The cardio-selective beta-blocker ICI 50,172 attenuates the haemodynamic response to exercise in hypertensive patients without affecting resting haemodynamics or peripheral resistance.
Intravenous administration of a new cardio-selective β-adrenergic blocking agent with intrinsic sympathetic activity, but, unlike propranolol, with no quinidine-like activity, produced insignificant haemodynamic effects at rest. On treadmill exercise, however, blood pressure, heart rate, cardiac output, and left ventricular work were reduced, peripheral resistance remaining unaltered.
Shinebourne et al. (1968) studied this question.