Strenuous physical exercise induced an immediate enhancement in fibrinolytic activity (P<0.03) and a 2.2-3.2 fold rise in von Willebrand factor, suggesting increased susceptibility to thrombotic events.
Observational (n=7)
Does strenuous physical exercise alter procoagulant and fibrinolytic activities in healthy male volunteers?
Strenuous exercise induces transient changes in procoagulant and fibrinolytic activities, which may potentially increase susceptibility to thrombotic events.
p-value: p=<0.03
Seven healthy male volunteers were subjected to exercise of short (STR; 1.7 km), middle (MTR; 4.8 km) and long (LTR; 10.5 km) term runs at a speed close to maximal capacity. Blood samples were drawn before, immediately after exercise and at intervals over the next 10 h. FVIIIR:Ag (von Willebrand factor) rose 2.2-3.2 fold and persisted at higher levels than baseline during the observation time. A spontaneous drop in FVII (p less than 0.03) was found immediately after STR (13.5 +/- 2.5%) and LTR (18.3 +/- 2.4%), whereas only a minor decrease (7.5 +/- 6.5%) occurred in MTR. The procoagulant activity of monocytes isolated from whole blood exposed to LPS showed a striking enhancement in STR and MTR. An immediate enhancement in fibrinolytic activity was found in all groups (p less than 0.03) assessed by increased plasma levels of t-PA and shortened whole blood clot lysis time (WBCLT). The transient shortening of WBCLT was succeeded by a tendency to prolongation of the lysis time. A 45-year old male differed markedly from the others by demonstrating an extreme and consistent prolongation of WBCLT. Thus, it has been speculated that strenuous exercise possibly makes a subject more susceptible to a thrombotic event.
Hansen et al. (1990) conducted an observational in Healthy (n=7). Strenuous physical exercise (short, middle, and long term runs) vs. Baseline (before exercise) was evaluated on Procoagulant and fibrinolytic activities (FVIIIR:Ag, FVII, t-PA, WBCLT) (p=<0.03). Strenuous physical exercise induced an immediate enhancement in fibrinolytic activity (P<0.03) and a 2.2-3.2 fold rise in von Willebrand factor, suggesting increased susceptibility to thrombotic events.