Two hours of jogging without fluids significantly increased plasma and renal ET-1 (+117% and +118%, P<0.01), an effect attenuated by isotonic fluid restitution (+2% and +3%).
Does 2 hours of jogging without drinking isotonic fluids increase plasma and urinary ET-1 compared to jogging with isotonic fluids in healthy non-professional athletes?
Plasma and renal ET-1 increase in response to exercise-induced hypovolaemia, a response attenuated by fluid replacement and related to AVP changes.
p-value: p=<0.01
Plasma endothelin (ET-1) and renal endothelin are two distinct functional systems involved in maintaining blood volume. To investigate whether plasma and renal ET-1 participate in the cardiovascular response to exercise-induced hypovolaemia, we studied changes in plasma and urinary ET-1 in healthy non-professional athletes after 2 h of jogging performed both without and with drinking isotonic fluids. After the run, which caused a 13% plasma volume (PV) reduction, plasma and renal ET-1 (+117% and +118%) increased significantly (all P < 0.01). Fluid loss restitution during the run significantly attenuated either the PV contraction (-1.2%) and plasma and renal ET-1 increase (+2 and +3%). At multiple regression analysis changes in AVP plasma concentration, and not in PRA or PV per se, were significantly related to ET-1 changes both in plasma and urine. The present findings indicate that both plasma and renal ET-1 participate in the cardiovascular response to hypovolaemia induced by long-lasting, dynamic exercise.
Serneri et al. (1997) studied Healthy non-professional athletes. 2 hours of jogging without isotonic fluids vs. 2 hours of jogging with isotonic fluids was evaluated on Changes in plasma and urinary ET-1 (p=<0.01). Two hours of jogging without fluids significantly increased plasma and renal ET-1 (+117% and +118%, P<0.01), an effect attenuated by isotonic fluid restitution (+2% and +3%).