Compared to borderline isolated systolic hypertension, normotension was associated with lower odds of fasting blood glucose > 5.5 mmol/l (OR 0.4; 95% CI 0.26-0.75) and BMI > 27 kg/m2.
Cross-Sectional (n=1,109)
Borderline isolated systolic hypertension is common and associated with an unfavorable cardiovascular risk profile, particularly regarding glucose metabolism and obesity, compared to normotension.
Odds Ratio: 0.4 (95% CI 0.26–0.75)
AIM: To assess the prevalence of borderline isolated systolic hypertension (borderline ISH), and to examine its association with other cardiovascular risk factors. METHODS: A cross-sectional community-based study was carried out in 1993-1994 in Skara, Sweden, including 1109 randomly chosen subjects > or = 40 years old. Normotension (NT) was defined as systolic blood pressure (SBP) or = 160 or DBP > or = 90 mmHg or ongoing treatment. RESULTS: The prevalence of borderline ISH (n = 203) by age was 4% in ages 40-49 years, 15% in ages 50-59 years, 28% in ages 60-69 years and 25% in ages 70-79 years. With borderline ISH as reference, normotensive subjects less often had fasting blood glucose > 5.5 mmol/l (odds ratio (OR): 0.4, 95% CI: 0.26-0.75), BMI > 27 kg/m2 (OR: 0.6, 95% confidence intervals (CI): 0.42-0.85) and known diabetes (OR: 0.4, 95% CI: 0.16-0.95). Hypertensive subjects more often had high density lipoprotein (HDL) cholesterol < 1.0 mmol/l (OR: 2.0, 95% CI: 1.35-2.99), a history of previous cardiovascular disease (CVD) (OR: 1.7, 95% CI: 1.01-2.72), known diabetes (OR: 2.4, 95% CI: 1.29-4.58) and microalbuminuria (men) (OR: 1.9, 95% CI: 1.15-3.11). CONCLUSION: Borderline ISH is a common condition. It is associated with a more unfavourable risk factor profile than that of normotensive subjects concerning primarily glucose metabolism and obesity. The prevalence of known diabetes increased with the degree of hypertension.
Bøg‐Hansen et al. (2001) conducted a cross-sectional in Borderline isolated systolic hypertension (n=1,109). Normotension vs. Borderline isolated systolic hypertension was evaluated on Fasting blood glucose > 5.5 mmol/l (OR 0.4, 95% CI 0.26-0.75). Compared to borderline isolated systolic hypertension, normotension was associated with lower odds of fasting blood glucose > 5.5 mmol/l (OR 0.4; 95% CI 0.26-0.75) and BMI > 27 kg/m2.