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All articles of this category Addition of lithiated methoxyallene 2 to imines provided the expected allenyl amines in good yield. These could be cyclized with base or with silver nitrate to a variety of 2,5-dihydropyrrole derivatives. Selected examples describe their conversion to pyrrolidin-3-ones or 3-methoxypyrroles. Most importantly, this 3 + 2cyclization method could also be applied to the synthesis of 2,5-disubstituted derivatives such as 26 - 28 and also to the preparation of the enantiopure compound 23 . methoxyallene - imine - allenyl amine - 2,5-dihydropyrrole - pyrrolidin-3-one - 3-methoxypyrrole
Amombo et al. (1999) studied this question.