January 1, 2000Japanese Journal of Electrocardiology6 citationsOpen Access

Long-term efficacy of antiarrhythmic drugs in the prevention of paroxymal atrial fibrillation; Significance of suffering period.

TKTakashi Komatsu SNShin Nakamura ESEita Saitou

Structured PICO

Does a shorter disease duration of paroxysmal atrial fibrillation improve the long-term efficacy of antiarrhythmic drugs in preventing progression to chronic atrial fibrillation?

Population

171 patients with paroxysmal atrial fibrillation (Paf), mean age 65±11 years, 121 males, 50 females. Stratified by disease duration: <1 month (Group A, N=56), 1-12 months (Group B, N=56), and ≥12 months (Group C, N=59).

Intervention

Antiarrhythmic drugs (randomly assigned to Class Ia/Ib initially after defibrillation; if recurrence, randomly changed to Class Ic or Bepridil)

Comparator

Comparison between disease duration groups (<1 month vs 1-12 months vs ≥12 months)

Outcome

Progression to chronic atrial fibrillation and mean duration of sinus rhythm maintenancehard clinical

Initiating antiarrhythmic drug therapy within 1 month of paroxysmal atrial fibrillation onset significantly improves long-term sinus rhythm maintenance and reduces progression to chronic atrial fibrillation.

Abstract

【目的】罹患期間からみた発作性心房細動 (paroxysmal atrial fibrillation: Paf) に対する抗不整脈薬の長期予防効果 (観察期間40.6±26.8ヵ月) を検討する.【方法】Paf171例 (男性121例, 女性50例, 平均年齢65±11歳) を対象に, 病歴期間1ヵ月未満 (A群, N=56) , 病歴期間1ヵ月以上12ヵ月未満 (B群, N=56) , 病歴期間12ヵ月以上 (C群, N=59) の3群に分けた.薬剤選択は, 除細動後無作為にIa・Ib群抗不整脈薬の内服開始し再発が無ければ内服継続, 再発がみられれば再除細動後, 無作為にIc群あるいはBepridilの内服変更とした, 【結果】抗不整脈薬の使用薬剤数はA群1.5±1.1剤, B群2.6±1.9剤, C群2.8±2.3剤, 心房細動慢性化例はA群1例 (1.8%) , B群8例 (14.3%) , C群13例 (22.0%) であり, いずれもA群に比しB群ならびにC群で有意に高値であり (P<0.05) , 平均洞調律維持期間はA群28.2±21.9ヵ月, B群18.1±17.7ヵ月, C群19.3±21, 1ヵ月であり, A群に比しB群ならびにC群で有意に低値であった (P<0.05) .

Ask AI

Helpful

Bookmark

View Full Paper

Cite This Study

Komatsu et al. (2000) studied this question.

synapsesocial.com/papers/6a968bbba45595e5080e2a83 https://doi.org/10.5105/jse.20.27

Ask AI

Helpful

Bookmark

View Full Paper

January 1, 2000Japanese Journal of Electrocardiology6 citationsOpen Access

Long-term efficacy of antiarrhythmic drugs in the prevention of paroxymal atrial fibrillation; Significance of suffering period.

TKTakashi Komatsu SNShin Nakamura ESEita Saitou

Structured PICO

Does a shorter disease duration of paroxysmal atrial fibrillation improve the long-term efficacy of antiarrhythmic drugs in preventing progression to chronic atrial fibrillation?

Population

Intervention

Antiarrhythmic drugs (randomly assigned to Class Ia/Ib initially after defibrillation; if recurrence, randomly changed to Class Ic or Bepridil)

Comparator

Comparison between disease duration groups (<1 month vs 1-12 months vs ≥12 months)

Outcome

Progression to chronic atrial fibrillation and mean duration of sinus rhythm maintenancehard clinical

Abstract

Ask AI

Helpful

Bookmark

View Full Paper

Cite This Study

Komatsu et al. (2000) studied this question.

synapsesocial.com/papers/6a968bbba45595e5080e2a83 https://doi.org/10.5105/jse.20.27

Ask AI

Helpful

Bookmark

View Full Paper