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October 1, 1972Journal of Virology67 citationsOpen Access

Isolation of Temperature-Sensitive Mutants of Murine Sarcoma Virus

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ESEdward M. ScolnickJSJohn StephensonSAStuart A. Aaronson

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Abstract

Three separate murine sarcoma virus nonproducer cell lines have been isolated which are temperature sensitive for the maintenance of transformation. In each case, a viral rather than a cellular genetic mutation is the reason for the temperature-sensitive effect. Superinfection of one of the mutants with murine leukemia virus overcomes the temperature-sensitive change in the transformed state.

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Scolnick et al. (1972) studied this question.

synapsesocial.com/papers/6a9698e4132cd8a75e578e3chttps://doi.org/10.1128/jvi.10.4.653-657.1972
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