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Summary The effect of surgery on thyroid hormone transport was studied in ten subjects undergoing vagotomy and pyloroplasty for chronic duodenal ulceration. Measurements of the serum protein bound iodine (PBI), thyrotrophic hormone (TSH), T4 binding capacities of the thyroxine binding proteins (TBPA and TBG), percentage and absolute free thyroxine (T4) and percentage free triiodothyronine (T3) were made before and after operation. Operation produced a sharp reduction in the maximal binding capacity of TBPA with no apparent change in TBG. There were significant increases in percentage and absolute free T4 and in percentage free T3. There was no change in PBI and no increase was demonstrated in TSH after operation. The changes appeared to be unrelated to the increase in adrenocortical hormones associated with injury. It is suggested that thyroid hormones may have an important role in post‐injury metabolism.
Kirby et al. (1973) studied this question.