Subjects with decreased CFVR (<2.5) had significantly higher baPWV (1848 vs 1548 cm/s; p<0.001), greater augmentation index, and greater pulse pressure compared to those with normal CFVR.
Observational (n=102)
Is large artery stiffness associated with reduced coronary flow velocity reserve in subjects without coronary and peripheral arterial disease?
Large artery stiffening is independently associated with reduced coronary flow velocity reserve, providing a potential mechanism for the higher cardiac event rate observed in patients with increased arterial stiffness.
Absolute Event Rate: 1848% vs 1548%
p-value: p=<0.001
BACKGROUND: Population studies have shown that increased large artery stiffness is an independent predictor of cardiovascular events. Experimental studies have shown that a stiff aorta is associated with decreased coronary blood flow. However, a link between large artery stiffness and coronary microvascular function in the clinical setting has not been demonstrated previously. OBJECTIVE: To evaluate the relationship between large artery stiffness and coronary flow velocity reserve (CFVR). PATIENTS AND METHODS: 102 consecutive subjects (mean (SD) age 62 (10) years) without coronary and peripheral arterial disease were enrolled in the study. After 15 minutes' rest, measurements were obtained of brachial-ankle pulse wave velocity (baPWV), augmentation index (AIx) from a carotid pulse tracing, and transthoracic echocardiographic measures, including coronary flow velocity in the left anterior descending coronary artery. In addition, coronary flow velocity during hyperaemia was measured during an intravenous infusion of adenosine triphosphate. CFVR was defined as the ratio of hyperaemic to basal coronary velocity. RESULTS: Subjects with decreased CFVR ( or = 2.5; n = 62). Multivariate analysis showed that AIx and PP were independent predictors of CFVR (r = -0.32, p<0.001 and -0.25, p = 0.02, respectively). CONCLUSIONS: The data suggest that large artery stiffening is linked to a reduction of CFVR, which may partially explain the higher cardiac event rate in patients with increased large artery stiffness.
Saito et al. (2007) conducted an observational in Subjects without coronary and peripheral arterial disease (n=102). Decreased CFVR (< 2.5) vs. Normal CFVR (≥ 2.5) was evaluated on brachial-ankle pulse wave velocity (baPWV) (p=<0.001). Subjects with decreased CFVR (<2.5) had significantly higher baPWV (1848 vs 1548 cm/s; p<0.001), greater augmentation index, and greater pulse pressure compared to those with normal CFVR.