In type 1 diabetic patients with nephropathy, a higher mean Z score of inflammatory biomarkers was significantly associated with increased mortality (HR 1.7; 95% CI 1.1-2.6; P=0.025).
Cohort (n=391)
Are biomarkers of endothelial dysfunction and inflammation associated with mortality, cardiovascular events, and GFR decline in type 1 diabetic patients?
Inflammatory and endothelial dysfunction biomarkers are significantly associated with long-term mortality, cardiovascular events, and GFR decline in type 1 diabetic patients with nephropathy.
Hazard Ratio: 1.7 (95% CI 1.1–2.6)
p-value: p=0.025
OBJECTIVE: We evaluated the association of biomarkers of endothelial dysfunction and inflammation with all-cause mortality and cardiovascular mortality and morbidity and decline in glomerular filtration rate (GFR) in type 1 diabetic patients. RESEARCH DESIGN AND METHODS: We prospectively followed 199 type 1 diabetic patients with diabetic nephropathy and 192 patients with persistent normoalbuminuria. Biomarkers were measured at baseline. RESULTS: We constructed two Z scores: the mean inflammatory Z score combined C-reactive protein, interleukin-6, soluble intercellular adhesion molecule (sICAM-1), and secreted phospholipase A2 and the mean Z score for endothelial dysfunction combined soluble vascular cell adhesion molecule 1, plasminogen activator inhibitor-1, and sICAM-1. The mean Z score of inflammatory biomarkers was associated with mortality and the combined end point in patients with diabetic nephropathy after multivariate adjustment (hazard ratio 1.7 95% CI 1.1-2.6; P = 0.025 and 1.5 1.1-2.2; P = 0.017). The mean Z score for endothelial dysfunction biomarkers was associated with mortality in a model adjusting for age and sex in patients with diabetic nephropathy (1.6 1.0-2.3; P = 0.031). The mean Z score for endothelial dysfunction correlated with decline in GFR (r = -0.243; P = 0.001); the correlation persisted after multivariate adjustment (coefficient -1.38 95% CI -2.27 to -0.50; P = 0.002). CONCLUSIONS: Mean Z scores of inflammatory biomarkers are significantly associated with all-cause mortality and cardiovascular morbidity and mortality in patients with nephropathy after multivariate adjustment. These data suggest that the high risk of cardiovascular disease in type 1 diabetes may be explained in part by inflammatory activity. Mean Z score of endothelial dysfunction correlated after multivariate adjustment with the rate of decline in GFR.
Astrup et al. (2008) conducted a cohort in Type 1 diabetes with or without diabetic nephropathy (n=391). Mean Z score of inflammatory biomarkers was evaluated on Mortality in patients with diabetic nephropathy (HR 1.7, 95% CI 1.1-2.6, p=0.025). In type 1 diabetic patients with nephropathy, a higher mean Z score of inflammatory biomarkers was significantly associated with increased mortality (HR 1.7; 95% CI 1.1-2.6; P=0.025).