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January 1, 1967Japanese Heart Journal37 citationsOpen Access

Transient Recurrent Ventricular Fibrillation due to Hypopotassemia with Special Note on the U Wave

KTKohji TamuraTTTakashi TamuraSYShoji Yōshida

Key Result

Transient recurrent ventricular fibrillation due to hypokalemia was successfully resolved with potassium chloride and spironolactone after initial treatment with ajmaline became ineffective.

Study Design

Type

Case Report (n=1)

Multicenter

No

PICO

P
Population
A 67-year-old female presenting with transient recurrent ventricular fibrillation and Adams-Stokes syndrome due to severe hypokalemia.
I
Intervention / Comparator
Potassium chloride and Ajmalin (Ajmalin up to 400 mg/day, Potassium chloride 6 Gm/day)
O
Primary Outcome
Resolution of ventricular fibrillation and Adams-Stokes attacks

Limitations

  • The underlying cause of hypokalemia remained unknown.

Abstract

IT is very rare that Adams-Stokes syndrome occurs in hypopotassemia and only 2 cases are reported in the literature.1) These cases were caused by atrioventricular block, though in this case the Adams-Stokes syndrome was caused by ventricular fibrillation that was recurrent, transient and reversible. The patient was, moreover, relieved by potassium chloride. Such a case was not reported yet in the literature as far as we know. The massive fused T and U wave inversion, the postextrasystolic alteration of it, the alternans of the U wave after the cessation of ventricular fibrillation and the postextrasystolic alteration of the U wave were seen in this case. These were very interesting signs in the electrocardiogram to resolve the ionic shift in the myocardium in these occasions.2) The antiarrhythmic drug of ajmalin was effective in the initial stage in this case, though it became ineffective in the further advanced stage of hypopotassemia. This finding is interesting, if we refer the ineffectiveness of quinidine in hypopotassemia which is shown experimentally.3) Such a rare case is presented with the review of the literature and the mechanisms are discussed.

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Cite This Study

Tamura et al. (1967) conducted a case report in Transient recurrent ventricular fibrillation due to hypopotassemia (n=1). Potassium chloride and Ajmalin was evaluated on Resolution of ventricular fibrillation and Adams-Stokes attacks. Transient recurrent ventricular fibrillation due to hypokalemia was successfully resolved with potassium chloride and spironolactone after initial treatment with ajmaline became ineffective.

synapsesocial.com/papers/6a9c3e5590ddd57cf2908f15https://doi.org/10.1536/ihj.8.652
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stokes-Adams syndrome, a rarely reported disease2025
  2. 2Paroxysmal Ventricular Standstill: A Rare Cardiac Manifestation of Syncope2020 · 10 citations
  3. 3PAROXYSMAL VENTRICULAR FIBRILLATION PRODUCING ADAMS-STOKES SYNDROME1952 · 25 citations
  4. 4Ventricular Arrhythmia and Stokes-Adams Syndrome1953 · 17 citations
  5. 5Recurrent Ventricular Fibrillation Related to Hypokalemia in Early Repolarization Syndrome2012 · 20 citations